FOLLOW EBF ON:
| This year, the EBF Focus meeting will host plenary sessions as well as a half day of chromatography and ligand binding focussed break out sessions. |
| 16.00h | 20.00h | Registration and Information Desk open | ||||
| 7.30h | 12.30h | Registration and Information Desk open | ||||
Morning plenary sessions |
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Introduction and aim of the meeting |
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| 8.30h | 8.45h | Welcome and introduction, aim of the meeting | Philip Timmerman (on behalf of EBF) |
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| 8.45h | 9.15h | Keynote: Bringing New Technologies into Regulatory Space | CT. Viswanathan (CT Viswanathan & Associates, Inc.) |
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Special Topics and Interesting Techniques |
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| Chair: Hans Mulder (Astellas) | ||||||
| 9.15h | 9.35h |
iHUMITE: A cost efficient and accurate human drug metabolite profiling workflow |
William van Dongen (TNO Triskelion) |
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| 9.35h | 9.55h | Advantages and recent developments in the use of photo-spray ionisation for quantitative bioanalysis | Martijn Hilhorst (PRA International) |
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| 9.55h | 10.15h | Pushing the limits of increased selectivity, dynamic range and sensitivity for bioanalytical applications | Bruce Thompson (AB Sciex) |
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| 10.15h | 10.45h |
Break |
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Alternative MS-techniques for quantitative bioanalysis |
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| Chair: Philip Timmerman (Janssen Research & Development) |
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| 10.45h | 11.10h | Keynote: Towards High Resolution MS in Regulated Bioanalysis | Benno Ingelse (MSD) |
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| 11.10h | 11.30h | Application of ICP-MS and LC-ICP-MS in Drug Development | Jaap Wieling (QPS) |
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| 11.30h | 11.50h | ICPMS and tailored sample preparation for unusual bioanalyical applications | Erik Baltussen (WIL) |
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| 11.50h | 12.10h | High Resolution and Accurate Mass Spectrometry for Specific and Sensitive Quantification of Target Compounds in Complex Matrices | Steven Watt (A&M) |
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| 12.10h | 12.30h | HR-MS in High Throughput Regulated Bioanalysis: A thorough and Practical Evaluation of Performance, Roubustness and Return on Investment | Fabio Garofolo (Algortihm Pharma) |
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| 12.30h | 12.50h | Accurate Mass MS/MS an Attractive Option For the Quantification of Biotherapeutics in DMPK Studies | Diego Rodriguez Cabaleiro (Waters Europe) |
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| 12.50h | 14.00h |
Lunch and poster session |
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Afternoon plenary sessions |
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Miniaturization and/or automation of sample preparation techniques? |
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| Chair: John Smeraglia (HLS) | ||||||
| 14.00h | 14.30h | Keynote presentation: Development of Quantitative Nanoscale Techniques for Ultra Trace Analysis of Biological Microsamples | Kevin Bateman (MSD) |
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| 14.30h | 14.50h | Blood microsampling and bioanalysis in preclinical species | Lieve Dillen (Janssen R&D) |
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| 14.50h | 15.10h | Capillary Microsampling: "Better science – Fewer animals" | Ove Jonsson (AstraZeneca) |
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| 15.10h | 15.30h | Microdialysis as a tool in drug research and development | Brigitte Buscher (TNO Triskelion) |
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| 15.30h | 15.50h | The Application of Solid - Phase Micro-Extraction and Micro-Sampling/ a Multipurpose Micro-Technique for Bioanalysis | Sheelan Ahmad (GSK) |
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| 15.50h | 16.15h |
Break |
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Tissue Analysis |
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Chair: Margarete Brudny-Kloeppel (Bayer Healthcare) |
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| 16.15h | 16.45h | Keynote presentation: We Can See - Mass Makes the Difference | Markus Stoeckli (Novartis) |
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| 16.45h | 17.05h | Maldi imaging of small histological tissue applied to ophthalmology: qualitative and quantitative approach in drug discovery | Jonathan Stauber (ImaBiotech) |
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| 17.05h | 17.25h | MALDI Tissue Imaging: More than Just a Pretty Picture? | Andrew McEven (Quotient Bioresearch) |
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| 17.25h | 17.45h | Some practical aspects in tissue analysis | Hermann Mascher (Pharm-Analyte Labor) |
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| 17.45h | 18.00h | EBF Topic team on tissue analysis: plans | Nathalie Mokrzycki (MSD) |
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Morning breakout sessions |
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Focus on Large molecules: Emerging platforms in support of LBA |
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| Chair: Neil Henderson (AstraZeneca) | ||||||
| 8.30h | 9.00h | Keynote presentation: New and Automated Technology Platforms in Bioanalysis | John Allinson (ICON Development Solutions) |
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| 9.00h | 9.20h | A Hybrid LBA-QPCR Technique (Proseek) for Improved Assay Sensitivity | Karen Dowers (CRL) |
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| 9.20h | 9.40h | Homogeneous immunoassay using AlphaLISA technology – the “no wash” high-throughput alternative to ELISA for PK, PD and immunogenicity measurement during drug development | Denise Sickert (Novartis) |
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| 9.40h | 10.00h | Mass Spectrometric Immunoassays | Bryan Krastins (ThermoFisher Scientific) |
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| 10.00h | 10.20h | Open Slot | Open Slot | |||
Focus on Small molecules: Miniaturization and diversification in LC-MS interfacing |
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| Chair: Benno Ingelse (MSD) | ||||||
| 8.30h | 9.00h | Keynote: Incorporating Multifunctionality into Microchip Separations | Sabeth Verpoorte (University of Groningen) |
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| 9.00h | 9.20h | Hatching sensitivity in Bioanalysis The promise of chip based micro LC/MS | Marc De Meulder (Janssen R&D) |
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| 9.20h | 9.40h | Capillary Scale LC/MS/MS for High Sensitivity Bioanalysis Is This A Reality and Where Are The Pit Falls | Robert Plumb (Waters Corporation) |
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| 9.40h | 10.00h | Micro LC/MS: Miniaturizing LC for LC/MS applications in bioanalysis |
Tina Settineri |
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| 10.00h | 10.20h | Going round again: Lessons learnt from establishment and validation of methods on the Gyrolab Workstation | Graig Stovold (Quotient Bioresearch) |
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| 10.20h | 10.50h |
Break |
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Morning plenary sessions |
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Applications and validation approaches for Emerging platforms in support of LBA |
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| Chair: Arjen Companjen (Crucell) | ||||||
| 10.50h | 11.20h | Keynote presentation: Challenges in Development and Validation of an Intracellular Cytokine Staining assay | Jenny Hendriks (Crucell) |
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| 11.20h | 11.40h | Validation of a PCR for the quantification of residual plasmid DNA in samples from a biodistribution study for a therapeutic RNA vaccine |
Carsten Lindemann (EUFETS GmbH) |
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| 11.40h | 12.00h | Case Studies on ultra-sensitive immunoanalytics based on Imperacer® (Immuno-PCR) in clinical settings. | Beena Punnamoottil (Chimera Biotec GmbH) |
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| 12.00h | 12.20h | Validation of a multiplexed cytokine panel in human serum using a Randox Evidence analyser and comparison to other platforms (Luminex and MSD) |
Jason Cook (AstraZeneca) |
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Plenary panel discussion |
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| 12.20h | 12.50h | Panel discussion connecting back on scope of FM | Philip Timmerman and C.T. Viswanathan | |||
| 12.50h | 14.00h |
Lunch and poster session |
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Afternoon plenary sessions |
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GBC feedback |
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| Chair: Peter van Amsterdam (Abbott Healthcare Products) | ||||||
| 14.00h | 14.10h | Feedback from GBC Harmonization team leaders Face to face (March 2012) | Peter van Amsterdam (on behalf of GBC) |
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14.10h |
14.40h |
Feedback and input A2 – Tiered approaches to method validation |
Philip Timmerman |
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| 14.40h | 15.30h | Feedback and input S teams | ||||
| S1 – Small molecule specific run acceptance harmonization team progress report |
Ben Gordon (on behalf of Servier) |
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| S2 – Small molecule specific assay operation | Steve White (GSK) |
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| S3 – Chromatographic run quality assessment | Stuart McDougall (Covance) | |||||
| Panel discussion | GBC-SC members and session presenters | |||||
| 15.30h | 16.00h |
Break |
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| 16.0h | 17.00h | Feedback and input L teams | ||||
| L1 – Large molecule specific run operation |
Chris Beaver (Pharmanet) |
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| L2 – Large molecule specific assay operation |
Chris Beaver (Pharmanet) |
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| L3 – Assay Formats | John Smeraglia (HLS) |
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| A8 – Documentation | Tom Verhaeghe (Janssen Research and Development) |
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| Panel discussion | GBC-SC members and session presenters | |||||
| 17.00h |
Closing remarks and Adjourn |
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Copyright 2012 EBF